Friday, February 3, 2012

1202.0433 (Jens Karschau et al.)

Optimal Placement of Origins for DNA Replication    [PDF]

Jens Karschau, J. Julian Blow, Alessandro P. S. de Moura
DNA replication is an essential process in biology and its timing must be
robust so that cells can divide properly. Random fluctuations in the formation
of replication starting points, called origins, and the subsequent activation
of proteins lead to variations in the replication time. We analyse these
stochastic properties of DNA and derive the positions of origins corresponding
to the minimum replication time. We show that under some conditions the
minimization of replication time leads to the grouping of origins, and relate
this to experimental data in a number of species showing origin grouping.
View original: http://arxiv.org/abs/1202.0433

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